What is Epitalon?
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) originally developed by Professor Vladimir Khavinson based on the naturally occurring pineal gland peptide epithalamin. This remarkable compound has gained recognition for its ability to activate telomerase, extend telomere length, and provide significant anti-aging benefits through cellular longevity mechanisms.
Telomerase Activator
Epitalon works by activating telomerase enzyme activity, allowing cells to maintain and extend their telomeres, which naturally shorten with age.
Cellular Longevity
By extending cellular lifespan through telomere protection, Epitalon supports healthy aging, improved immune function, and enhanced tissue repair mechanisms.
Research and Potential Benefits
Epitalon's primary benefit is its ability to activate telomerase enzyme and extend telomere length in human somatic cells.
- ✓ Telomerase Induction: Activates the catalytic subunit of telomerase enzyme in previously inactive cells.
- ✓ Telomere Extension: Studies show up to 33% increase in telomere elongation in human fibroblasts.
- ✓ Cellular Lifespan: Enables cells to overcome division limits and continue healthy proliferation.
Epitalon demonstrates remarkable geroprotective effects, extending lifespan and improving health span through multiple mechanisms.
- ✓ Lifespan Extension: Studies show up to 28% decrease in overall mortality and improved longevity.
- ✓ Antioxidant Properties: Powerful free radical scavenging activity reduces oxidative stress and cellular damage.
- ✓ Immune Function: Enhances cellular and humoral immunity while reducing age-related immune decline.
Epitalon has an excellent safety profile with minimal reported side effects across numerous animal and human studies.
- ! Research Use: Currently available as a research peptide requiring proper clinical supervision and monitoring.
- ! Minimal Side Effects: Human trials report excellent tolerability with no significant adverse reactions.
- ! Long-term Studies: Extended animal studies show improved mortality without toxicity concerns.
References & Citations
- Khavinson, V. K., et al. (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine, 135(6), 590-592. Source.
- Anisimov, V. N., et al. (2001). Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mechanisms of Ageing and Development, 122(1), 41-68. Source.
- Khavinson, V. K., & Morozov, V. G. (2003). Peptides of pineal gland and thymus prolong human life. Neuroendocrinology Letters, 24(3-4), 233-240. Source.
Ask Dr. John About Epitalon
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